Team Leader : Jian Sheng LIN - +33 (0)0478777116

Equipe Physiologie intégrée du système d'éveil,
Faculté de Médecine, Université Claude Bernard Lyon 1,
8 avenue Rockefeller,
69373 Lyon Cedex 08,
France

Phone : +33 (0)478777041 - Fax : +33 (0)478777150

Our goal is to unravel the mechanisms of wake and associated pathologies: narcolepsy, excessive daytime sleepiness, insomnia, metabolic disorders, sudden infant death syndrome.

From a basic research standpoint, we dissect the mechanisms of wake through the study of the specific, complementary and synergistic roles of histaminergic and orexinergic neurons in particular. Using specific knock out mice and detailed behavioral and electroencephalographic measures, we will determine how the two systems interact synergistically and integrate into the central mechanisms of sleep-wake alteration (JS Lin, K Sakai). We also use intracellular recordings, local field potentials and biosensors to study the properties of the cortical network during different types of behavioral states, the respective role of diffuse ascending systems and specific cerebral nuclei, and the mechanisms and effects of extra-synaptic variations of neurotransmitter (S. Crochet, S Marinesco).

From a physio-pathological and translational research standpoint, we work on 1) developing therapeutic approaches for narcolepsy and excessive daytime sleepiness using our knowledge of histaminergic and orexinergic systems (P Franco, JS Lin), 2) investigating the interactions between sleep loss and metabolic disorders in lean subjects and obese patients and in animal models combining sleep/wake and metabolic alterations (K. Spiegel), and 3) identifying new signaling pathways and biomarkers associated with wake thanks to Drosophila molecular genetics (L. Seugnet).

Our work is thus characterized by the use multidisciplinary methodological approaches: electrophysiology and behavior, biosensors, clinical investigations, molecular genetics, and the development of tools for both diagnostic and therapy.

Please click on individual names in the list below for more information.

Methodology

  • Electrophysiology (EEG, local field potential, intra and extracellular recordings in behavioral mice and cats)
  • Polysomnography in animals (mouse, cat) and humans (adult,child)
  • Biosensors (electrochemistry)
  • Immunohistochemistry
  • Neuro-behavioural testing
  • Neuropharmacology
  • Cognitive, metabolic and endocrine testing in humans
  • Animal models for sleep disorders (mouse, cat)
  • Sleep molecular genetics in Drosophila 

Keywords : waking, arousal, sleep, slow wave sleep, REM sleep, cortical activation, posterior hypothalamus, histamine, orexin, sleep-wake disorder, somnolence, waking substance, mesopontine tegmentum, neurophysiology, cat, mouse

  1. Brief history of the laboratory
  2. Scientific presentation of the laboratory (pdf)
  3. List of publication
  4. Présentation Scientifique Grand public (Français)
  5. Bref historique du laboratoire (Français)
  6. Group pictures

Les 28 membres
# Name PositionOrg.TeamsPubMed
1 LIN Jian Sheng DR2 INSERM CRNL WAKING TEAM (Team Leader)CRNL WAKING TEAM » CRNL WAKING TEAM (Team Leader)  
2 PERROT Françoise SARCN INSERM CRNL WAKING TEAM (Secretary)  
# Name PositionOrg.TeamsPubMed
1 ACHAINTRE Laetitia   INSERM CRNL WAKING TEAM » CRNL WAKING TEAM  
2 AKAOKA Hideo CR1 CNRS CRNL WAKING TEAM » CRNL WAKING TEAM  
3 ANACLET Christelle   INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
4 BUDA Colette IE INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
5 CESPUGLIO Raymond DR1+HDR INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
6 CHALLAMEL Marie Josephe CR1 INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
7 CROCHET Sylvain CR1 INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
8 FERNANDEZ Laura THESE INSERM CRNL WAKING TEAM » CRNL WAKING TEAM  
9 FRANCO Patricia MCUPH HOSP-UNIV CRNL WAKING TEAM » CRNL WAKING TEAM
10 GENTET Luc CR1 INSERM CRNL WAKING TEAM » CRNL WAKING TEAM  
11 GORMAND Frédéric PH HOSP CRNL WAKING TEAM » CRNL WAKING TEAM
12 GRANDJEAN Estelle AGTU UNIV CRNL WAKING TEAM » CRNL WAKING TEAM  
13 GUIDON Gérard AI INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
14 GUYON Aurore     CRNL WAKING TEAM » CRNL WAKING TEAM  
15 INOCENTE Clara THESE HOSP CRNL WAKING TEAM » CRNL WAKING TEAM  
16 KOCHER Laurence MCU PH HOSP CRNL WAKING TEAM » CRNL WAKING TEAM  
17 LIN Jian Sheng DR2 INSERM CRNL WAKING TEAM (Team Leader)CRNL WAKING TEAM » CRNL WAKING TEAM (Team Leader)  
18 MARINESCO Stéphane CR1 INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
19 MAUCLER Caroline MAST2   CRNL WAKING TEAM » CRNL WAKING TEAM  
20 NEUZERET Pierre Charles PDOC   CRNL WAKING TEAM » CRNL WAKING TEAM
21 ONEN Saban Hakki PH HOSP CRNL WAKING TEAM » CRNL WAKING TEAM  
22 PERIER Magali AI inserm CRNL WAKING TEAM » CRNL WAKING TEAM  
23 RAOUX Aude THESE HOSP-UNIV CRNL WAKING TEAM » CRNL WAKING TEAM  
24 SAKAI Kazuya DR2 INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
25 SEUGNET Laurent CR1 INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
26 SPIEGEL Karine CR1 INSERM CRNL WAKING TEAM » CRNL WAKING TEAM
27 VASYLIEVA Natalia THESE INSERM CRNL WAKING TEAM » CRNL WAKING TEAM  
Dernière modification le Lundi 18 Novembre 2013 à 10:50:27.