Grade : CR1 (Chargé de Recherche de 1ère classe)
Appartenance : INSERM (Institut National de la Santé et de la Recherche Médicale)


Equipe Physiologie intégrée du système d'éveil,
Faculté de Médecine, Université Claude Bernard Lyon 1,
8 avenue Rockefeller,
69373 Lyon Cedex 08,

Publications dans les bases de données en ligne :

  • Afficher la bibliographie de Karine Spiegel dans PubMed
  • Rechercher author:"K SPIEGEL" [Biologie+Médecine] dans Google Scholar

Research Interest

Sleep curtailment has become an endemic behavior in modern society. Our landmark experimental studies have demonstrated that recurrent partial sleep deprivation in healthy young lean adults results in reduced glucose tolerance, insulin resistance, elevated evening cortisol levels, increased cardiac sympatho-vagal balance, and a risk of weight gain resulting from reduced anorexigenic leptin levels, increased orexigenic ghrelin levels and increased hunger and appetite (see PDFs of selected publications). These results suggest that sleep loss may be a risk factor for obesity and type 2 diabetes. Consistent with these findings, an ever-increasing number of cross-sectional and longitudinal epidemiologic studies report an association between short sleep and the prevalence or incidence of obesity and diabetes. In order to provide new insights into the role of sleep for metabolic health and to propose novel therapeutic approaches, our current work focuses on the impact of sleep duration and sleep quality on the pathophysiology of metabolic diseases in adolescents and middle-aged subjects who are lean, obese and/or suffer from sleep disordered breathing. Our main objective is to determine the putative therapeutic effects of increasing sleep duration on metabolic outcomes.



 I obtained a PhD in Neuroscience in 1995 from the University of Strasbourg, France. My project investigated the relationships between sleep and physiological functions, especially the endocrine system. Continuing my interest in the effects of sleep on physiological functions and health, I took post-doctoral positions at the University of Chicago (Sleep, Chronobiology and Neuroendocrinology Research Laboratory headed by Prof. Eve Van Cauter) and then at the free University of Brussels in Belgium. My research aimed to delineate the effect of a sleep debt on electroencephalographic patterns, metabolic, hormonal, cardiovascular, cognitive and immunological functions in healthy young adults. Since 2007, I am a tenured a scientist of the French National Institute of Health and Medical Research (INSERM).


Selected publications (pdfs available below)

 SPIEGEL K., LEPROULT R., VAN CAUTER E. Impact of a sleep debt on metabolic and endocrine function. Lancet, 354 (1999), 1435-1439.

SPIEGEL K., SHERIDAN J.F., VAN CAUTER E. Effect of sleep deprivation on response to immunization. JAMA, 288 (2002), 1471-1472.

       SPIEGEL K., LEPROULT R., L'HERMITE-BALERIAUX M., COPINSCHI G., PENEV P., VAN CAUTER E. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J. Clin. Endocrinol. Metab., 89 (2004), 5762-71.

SPIEGEL K., TASALI E., PENEV P., VAN CAUTER E. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Annals of Internal Medicine, 141 (2004), 846-50.


SPIEGEL K., Tasali E, Leproult R, VAN CAUTER E. Effects of poor and short sleep on glucose metabolism and obesity risk. Nature Reviews Endocrinology, 5 (2009): 253-261.


Members of the Lab involved in this research


MCUPH (Maître de conférences des universités - Praticien hospitalier)

Patricia Franco


PhD student:

Aurore Guyon


Research Master Student

Corinne Langrand



Prof. P. Peigneux (Unité de Recherches en Neuropsychologie et Neuroimagerie Fonctionnelle (UR2NF), Université Libre de Bruxelles, Belgique)

Prof. G. Copinschi (Laboratoire de Médecine Expérimentale ,Université Libre de Bruxelles, Belgique)

Prof. E. Van Cauter (Sleep, Chronobiology and Neuroendocrinology Research Laboratory, University of Chicago, USA)


  1. Book chapters
  2. Honors and awards
  3. PDFs of selected publications
  1. équipe : Integrative Physiology of the Brain Arousal Systems

Dernière modification le Jeudi 25 Aout 2011 à 14:43:44.