Brief history of the laboratory
Our laboratory was initially funded and directed by Pr. Michel Jouvet and focused on the neurobiological mechanisms regulating sleep and paradoxical sleep in particular, (INSERM-U52/CNRS-URA1195, Département de Médecine Expérimentale à l’Université Claude Bernard, 1957-1998, then INSERM-U480, 1998-2002, directed by Dr. Raymond Cespuglio). In 2004 we created a new team: “integrated physiology of brain arousal system” focused on the central mechanisms responsible for the physiology and the maintenance of wake (INSERM-U628 directed by Jian-Sheng Lin). Since January 2011, our team is part of the Lyon Neuroscience Research Center (Team WAKING). Our research is multi-disciplinary and includes fundamental as well as clinical aspects: mouse of models of somnolence and narcolepsy using integrated physiology and state of the art electrophysiology, development of biosensors, pediatric narcolepsy, metabolic consequences of extended wake, molecular-genetics of sleep/wake regulation.